COVID-19 is rapidly spreading around the world, and currently, all efforts to combat the coronavirus are aimed at anti-epidemic measures and the creation of new antiviral drugs and vaccines. In the absence of etiotropic therapy, pathogenetic therapy, aimed at the critical factors of the pathogenesis of severe conditions arising in patients, becomes essential. It is highly advisable to include various ozone therapy methods in the complex of therapy for patients with COVID-19 by researching the mechanisms of medical ozone action.
Recently, several articles have appeared in the literature on the rather high efficiency of ozone therapy in new coronavirus (SARS-CoV-2) infection, which is due to the mechanisms of its biological action:
Ozonides, formed as a result of ozonolysis of unsaturated fatty acids, modify cell membranes, which provide intensification of enzyme systems and thereby enhance metabolic processes in the production of energy substrates.
The immunomodulatory effect of ozone is based on its ability to activate phagocytosis through the formation of peroxides and stimulate the production of cytokines by lymphocytes and monocytes.
Modification of membranes of blood corpuscles and ultrastructural organization of the vascular bed, a decrease in blood viscosity lead to an improvement in microcirculation and gas exchange at the tissue level.
There is a positive experience in the use of systemic ozone therapy for coronavirus infection in China, Spain, Italy, the USA, and several other countries.
Ozonized saline for COVID-19
Ozone is also effective for the disinfection of premises (gas phase), human skin (ozone creams containing active oxygen).
Among the biological effects of ozone, traditionally, the main place is occupied by bacteria, fungi, and viricidal effects. This property of ozone is used for local, external use in various forms (gas phase, solution, ozonized creams, oils, fats), especially in high concentrations. At the same time, unlike many known antiseptics, ozone does not irritate. It does not destroy the integumentary tissues of a person because, unlike pathogenic microorganisms, the human body has a powerful antioxidant defense system.
There is every reason to believe that systemic ozone therapy could potentially be beneficial for SARS-CoV-2. The electrophilic ozone molecule can react with a pair of free nitrogen electrons in N-acetylglucosamine, which is found in the host cell’s viral acceptors. This reduces the sensitivity of cells to viruses and eliminates the phenomenon of addiction. Moreover, it was found that ozone can inactivate the virus both extracorporeally and inside cells.