XENON usage in hypoxic-ischemic injury (HI)

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2 years ago
xenon therapy

The development of modern medicine does not stand still, innovative technologies are becoming more in demand, and therefore newer medical equipment and skills are required. Today, the use of xenon inhalations is widely used in advanced clinics and medical centers.

One of the promising methods of therapy is the use of xenon. The NMDA receptor antagonist has been approved in Europe for general anesthesia and has shown promising results as a neuroprotective drug. Xenon is superior to other NMDA receptor antagonists as a potent excitotoxic damage blocker and acts by inhibiting a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid and kainate receptors, decreasing glutamate secretion and affecting ion channels.

The introduction of new directions for the effective treatment of children with acute neurological pathology requires additional research and the development of protocols for assisting such children and educational programs for medical personnel.

Xenon gas and its benefits

The inert gas is utterly harmless to the human body, its main properties are:

  1. non-toxic;
  2. has no side effects;
  3. does not cause allergies;
  4. does not transform;
  5. excreted from the body in 3-4 minutes.

The above properties and medicinal properties indicate that medical xenon gas has a positive effect on humans.

What is xenon gas used for?

Xenon inhalation, first of all, has an excellent analgesic effect and acts as an antidepressant, is used to stimulate the immune system. As a preventive measure, such inhalations can be carried out against fatigue and anxiety to improve metabolic processes. A whole course based on xenon gas will allow to regain strength, improve health, and mental performance. Also, medical gas xenon will help to restore a long and sound sleep.
The use of xenon in pulmonology for the relief of hypoxic conditions turned out to be promising: in the complex therapy of acute respiratory failure of various origins, with tissue hypoxia in the brain, liver, kidneys, intestines. The anti-inflammatory and immunomodulatory effect of xenon can be used to treat the bronchopulmonary system’s inflammatory diseases, especially since there is already evidence of its anti-allergic effect.

It was found that medical xenon has a pronounced antidepressant, antipsychotic effect, which helps stabilize the indices of the autonomic nervous system.

However, along with these clinical possibilities, the data of works on the effectiveness of xenon use in patients with a somatic profile look especially promising. Moreover, it turned out that the uniqueness of the therapeutic effect of xenon is its system-wide effect with the restoration of regulatory processes in the body at various levels from general to local. The stabilizing effect of xenon continues after the cessation of inhalation: after a single session 2-3 hours, after 5 sessions 10-12 hours, and after 10 – up to 24 hours.

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Research is underway on the possibility of using Xe with other drugs

According to the data obtained, its combination with dexmedetomidine in vivo reduces the degree of the brain tissue damage that develops because of hypoxia. Besides, a decrease in the severity of hypoxic damage to the nervous tissue was revealed upon independent preconditioning with a combination of Xe and sevoflurane.

The neuroprotective properties of Xe suggested that its use would be promising in pediatric anesthesia practice. This gas is devoid of neurotoxic effects that can damage the developing brain. It is especially important for children under three years of age.

According to many authors, the list of diseases in which the use of xenon therapy is recommended is unusually wide and covers almost all the states. At the same time, xenon (post-xenon) therapy has mainly relative contraindications. However, it is indicated that the method should be used with great care in debilitated patients, pregnant women.

The absolute contraindications for the appointment of xenon therapy include:
– epilepsy;
– the presence of cysts, cavities in the lungs, as well as bronchial fistulas;
– acute pneumonia.

Relative contraindications are:
– acute ENT pathology;
– associated acute respiratory infections;
– post-traumatic encephalopathy without signs of epilepsy;
– the possibility of a hypoglycemic state (individual approach).

It can be concluded that medicine is on the verge of discoveries in the development of effective technologies for prevention, treatment, and rehabilitation based on the use of gas xenon. The broadest therapeutic spectrum of its effects and the almost complete absence of side effects are based on xenon modulation of the physical state of water.

References 

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